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Genomic imprinting is the process by which the monoallelic expression of certain genes necessary for homeostasis in healthy individuals is ensured by methylation of those regions on one of the two alleles. The methylation status of each allele depends on the parental origin of the chromosome, with some regions being silenced on the maternally-inherited allele and others on the paternally-inherited allele. Disruptions of the monoallelic expression pattern of genes across multiple genomic loci are referred to as multi-locus imprinting disturbances (MLIDs).
SALSA® MLPA® Probemix ME034 Multi-locus Imprinting is an assay for the detection of aberrant methylation of one or more sequences in 14 differentially methylated regions (DMRs) on eight different chromosomes and aids in the study of MLIDs.
ME034 Multi-locus Imprinting just received a major update, with the recently released D1 version featuring several new and improved target and reference probes that expand the differentially methylated regions investigated and ensure an even more robust assay output.