Choose your country to see the products for your location

P201 CHARGE

SALSA MLPA Probemix P201 CHARGE detects copy number variations in the CHD7 gene.

Specifications

Contents: 49 MLPA probes, including 41 probes for CHD7.

Tissue: human genomic DNA.

Application: research on CHARGE syndrome.

For research use only (RUO). Not for use in diagnostics.

Quick links

List Prices Documentation

General information

The SALSA MLPA Probemix P201 CHARGE is a research use only (RUO) assay for the detection of deletions or duplications in the CHD7 gene, which is associated with CHARGE syndrome.

CHARGE syndrome is an autosomal dominant disorder that affects many areas of the body and has an incidence of approximately 1:10.000. The pattern of malformations varies among individuals with this disorder, and infants often have multiple life-threatening medical conditions. The term CHARGE is an acronym for the set of clinical features observed in patients and stands for Coloboma, Heart disease, Atresia choanae, Retarded growth and retarded development and/or CNS anomalies, Genital hypoplasia, and Ear anomalies and/or deafness.

Mutations in the Chromodomain Helicase DNA-Binding Protein 7 (CHD7) gene have been found to be responsible for more than half of the CHARGE syndrome cases. CHD7 is the only gene currently known to be associated with CHARGE syndrome.

The CHD7 gene has 38 exons, spans ~189 kb of genomic DNA, and is located on chromosome 8q12.2, about 61 Mb from the p-telomere.

More information is available at https://www.ncbi.nlm.nih.gov/books/NBK1117/.

Regulatory status

SALSA MLPA Probemix P201 CHARGE is for research use only (RUO) in all territories.

Product documentation

Version C4

Other versions

Contact us for earlier versions.

List prices

Product

Item no.
Description
Technology
Price
P201-025R
SALSA MLPA Probemix P201 CHARGE – 25 rxn
MLPA
€ 286.00
P201-050R
SALSA MLPA Probemix P201 CHARGE – 50 rxn
MLPA
€ 560.00
P201-100R
SALSA MLPA Probemix P201 CHARGE – 100 rxn
MLPA
€ 1096.00

Required reagents

A general SALSA MLPA Reagent Kit is required for MLPA experiments (to be ordered separately).

Item no.
Description
Technology
Price
EK1-FAM
SALSA MLPA Reagent Kit – 100 rxn – FAM (6 vials)
MLPA MS-MLPA
€ 348.00
EK1-CY5
SALSA MLPA Reagent Kit – 100 rxn – Cy5 (6 vials)
MLPA MS-MLPA
€ 348.00
EK5-FAM
SALSA MLPA Reagent Kit – 500 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK5-CY5
SALSA MLPA Reagent Kit – 500 rxn – Cy5 (5×6 vials)
MLPA MS-MLPA
€ 1600.00
EK20-FAM
SALSA MLPA Reagent Kit – 2000 rxn – FAM (5×6 vials)
MLPA MS-MLPA
€ 6152.00

Price details & ordering

The prices above are list prices for direct orders from MRC Holland. Contact us for a quote that takes discounts and additional costs (such as shipping costs) into account. Different prices apply for orders through one of our sales partners; contact your local supplier for a quote.

More information about ordering & prices

Positive samples

Inclusion of a positive sample is usually not required, but can be useful for the analysis of your experiments. MRC Holland has very limited access to positive samples and cannot supply such samples. We recommend using positive samples from your own collection. Alternatively, you can use positive samples from an online biorepository, such as the Coriell Institute.

See this support article for commercially available positive samples that can be used with this product.

Resources

General MLPA resources

MLPA education

This site uses cookies to help improve your online experience. Learn more
No, thank you accept

Sign in

Don't have an account? Create one

Forgot password?

Select Your Country

Choose your country to see the products for your location